S. aureus mechanisms to initiate systematic infections. When S. aureus penetrates the skin’s natural defenses or spread through a biofilm that might develop on indwelling medical equipment, systemic infection is commonly the result. By actively attacking and killing immune cells like neutrophils in the circulation with cytolytic toxins, the bacteria can also remain in these cells and spread throughout the body, the bacteria can also spread through the bloodstream and invade more cells. Many bacterial factors, including particular surface proteins, toxins, exoenzymes and other compounds, can affect the development of an abscess later on [1]. .