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. Author manuscript; available in PMC: 2024 Jul 3.
Published in final edited form as: Neuron. 2020 Mar 3;106(3):482–497.e4. doi: 10.1016/j.neuron.2020.02.005

Figure 8. Synchronous propagation of preBötC activity to motor nuclei.

Figure 8.

Diagrammatic representation of synchronized preBötC output that propagates through premotor and motor inspiratory networks. Synchrony arises from correlated activity of preBötC rhythmogenic neurons, which are SST−, and propagates via preBötC output neurons, a subset of which are SST+, to inspiratory premotoneurons, in, e.g., parahypoglossal nucleus (paraXII) and rostral ventral respiratory group (rVRG) to inspiratory motoneurons, e.g., XII and phrenic motor nucleus. MFOs = Medium Frequency (15–50 Hz) Oscillations; HFO = High Frequency (50–120 Hz) Oscillations. The schematic is based on data presented here as well as in (Christakos et al., 1991; Ellenberger et al., 1990; Feldman et al., 1980; Funk and Parkis, 2002; Huang et al., 1996; Liu et al., 1990; Mitchell and Herbert, 1974; Parkis et al., 2003; Schmid et al., 1990; Tan et al., 2010; Wang et al., 2002; Yang and Feldman, 2018).