Table 2.
Cox Regression of Major Groups for Cause-Specific Long-term Mortality: Patients With Critically Ill Sepsis vs Weighted Controls by Follow-up Period
| aHR (95% CI) | |||||
|---|---|---|---|---|---|
| Long-term Mortality | First Month | Months 2–12 | Years 1–3 | Years 3–5 | Years >5 |
| All cause | 58.1 (47.6–70.9) | 3.0 (2.8–3.2) | 1.8 (1.7–1.9) | 1.9 (1.7–2.0) | 1.6 (1.5–1.8) |
| Infectious diseasesa | 189.5 (89.4–401.6) | 6.3 (5.1–7.9) | 2.1 (1.7–2.7) | 2.2 (1.7–2.9) | 1.9 (1.4–2.7) |
| Neoplasms | 21.7 (14.5–32.3) | 2.7 (2.4–3.1) | 1.9 (1.7–2.2) | 1.8 (1.6–2.1) | 1.3 (1.0–1.5) |
| Diseases of the blood and blood-forming organs | ∞b | 3.0 (1.2–7.5) | 0.8 (.2–3.3) | 6.2 (2.7–14.4) | 4.2 (1.6–11.0) |
| Endocrinologic and metabolic disorders | 41.6 (23.3–72.2) | 2.6 (1.9–3.5) | 1.1 (.7–1.5) | 2.1 (1.5–3.0) | 2.2 (1.3–3.7) |
| Mental and behavioral disorders | 17.8 (10.7–29.6) | 1.6 (1.1–2.4) | 1.2 (.9–1.7) | 1.3 (.8–2.1) | 1.2 (.8–1.7) |
| Nervous system disease | 51.0 (29.3–88.7) | 2.7 (1.9–3.9) | 1.9 (1.4–2.6) | 2.0 (1.4–2.8) | 1.4 (1.0–2.2) |
| Circulatory disease | 25.1 (19.4–32.6) | 2.4 (2.1–2.7) | 1.6 (1.4–1.7) | 1.8 (1.6–2.1) | 1.6 (1.4–1.9) |
| Respiratory disease | 140.0 (63.5–308.4) | 2.2 (1.6–3.0) | 2.0 (1.5–2.6) | 1.7 (1.1–2.8) | 2.1 (1.5–2.9) |
| Digestive system disease | 244.9 (124.0–483.7) | 4.4 (2.5–7.6) | 3.2 (2.4–4.4) | 2.7 (1.8–3.9) | 2.7 (1.8–4.2) |
| Musculoskeletal disease | 626.0 (170.3–2301.3) | 5.1 (2.4–10.6) | 2.4 (1.3–4.5) | 3.1 (1.0–9.2) | 3.7 (1.6–8.5) |
| Genitourinary disease | 320.1 (54.1–1895.2) | 3.9 (2.4–6.1) | 3.0 (2.0–4.6) | 1.3 (.6–2.8) | 1.9 (1.0–3.5) |
aHRs were estimated by Cox regression of major groups for cause-specific long-term mortality in patients who were critically ill with sepsis and treated in an intensive care unit (2008–2019) as compared with weighted controls from the background population for different follow-up periods.
Abbreviation: aHR, adjusted hazard ratio.
aThe category of infectious diseases was expanded to include several codes that relate to infectious diseases but belong to other chapters.
bEstimation not possible due to no controls with outcome.