Fig 6. SGLT2 mRNA expression in the kidneys of cats and dogs.

SGLT2 location was analyzed using in situ hybridization (ISH) in adult cats, young cats, and adult dogs. SGLT2-positive (⁺) reactions (arrowheads) were observed in the cytoplasm or nuclei of epithelial cells of proximal convoluted tubules (PCTs) but not in those of proximal straight tubules (PSTs), distal tubules (DTs), or collecting ducts (CDs) in adult and young cats and adult dogs. In adult cats, SGLT2⁺ reactions were observed in the epithelial cells of PST^LD+ but not in those of PST^LD- cats (the dotted line denotes the border between two segments). Resolution of anatomical or histological images: 300 × 300 dpi. Bars = 50 μm.