Table 3. An updated list for ExoIII activities.

Substrates	Preferred structures	Activities	Products	Key references
dsDNA	With 3′ phosphonate	3′ phosphatase	Phosphate	Richardson and Kornberg, 1964
	Containing AP	Endonuclease	ssDNA gap on DNA	Rogers and Weiss, 1980
	Natural DNA	Exonuclease	Phosphate, 5′ mononucleotides, ssDNA	Richardson et al., 1964
RNA	RNA/DNA hybrid	RNase H	Mono-ribonucleotide, ssDNA	Weiss et al., 1978
ssDNA	Containing AP	Active (less than dsDNA)	Oligos	Shida et al., 1996
	Nonstructural ssDNA	Exonuclease and endonuclease activities	Mononucleotide, Oligos	This study