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. Author manuscript; available in PMC: 2024 Jul 3.
Published in final edited form as: Cell Host Microbe. 2023 Oct 30;31(11):1850–1865.e5. doi: 10.1016/j.chom.2023.10.004

Figure 2. Phenotypic analysis of DENV1/3 E glycoprotein recombinant viruses.

Figure 2.

(A) Virus growth. Vero81 NHP cells were inoculated in triplicate and virus titers were measured by fluorescent foci units (FFU) at 48 h after infection, blue circles = triplicate titers.

(B) hmAB neutralization phenotypes. Confirmation of DENV1 and 3 epitopes in the DENV1/3 EDI, EDII, and EDIII panel plus parental strains using DENV1 and 3 mAb arrays.

(C) Western blots. E and prM proteins were visualized through western blot and (D) Virus Maturation Status. prM/E ratios determined, with lower numbers indicating greater maturity.