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. 2024 Jul 3;15:5602. doi: 10.1038/s41467-024-49930-6

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Schematic representation illustrating the process of adding EX527 in Kat8^d/d mTSCs. The graphic elements were created by figdraw. b Immunoblot analysis of CDX2, EOMES and H4K16ac in Kat8^d/d mTSCs with or without EX527. c Immunofluorescent staining of CDX2 and H4K16ac in Kat8^d/d mTSCs with or without EX527. d The quantitative results of C. Data are representative of three independent experiments (n = 3) and values are normalized to Kat8^f/f control group and expressed in mean ± SEM. **P < 0.01, ***P < 0.001. Source data are provided as a Source Data file. e Schematic representation depicting the application of EX527 treatment on Kat8^d/d embryos. The graphic elements were created by figdraw. f Immunofluorescent staining of CDX2, AP2γ and CK8 in Kat8^f/f, Kat8^d/d and EX527 treated Kat8^d/d embryos. g Quantification of CDX2⁺ cells or AP2γ⁺ cells in implantation sites of the indicated genotypes. Each dot in the column represents one implantation site (E6.5, n = 6 for Kat8^f/f, n = 6 for Kat8^d/d, n = 6 for Kat8^f/f + EX527; E7.5, n = 6 for Kat8^f/f, n = 6 for Kat8^d/d, n = 6 for Kat8^f/f + EX527; E8.5, n = 6 for Kat8^f/f, n = 6 for Kat8^d/d, n = 2 for Kat8^f/f + EX527). Two-tailed unpaired Student’s t-test. Error bars, mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. (n = 3 mice for Kat8^f/f, n = 3 mice for Kat8^d/d, n = 3 mice for Kat8^f/f + EX527). Source data are provided as a Source Data file.