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. 2024 Jul 3;14:15315. doi: 10.1038/s41598-024-66173-z

Table 1.

The statistical results for the developed binary active/inactive classifiers for different CDK groups. The models were evaluated in terms of sensitivity, specificity, precision, accuracy, and Mathew-correlation coefficient (MCC).

Model Class Precision Sensitivity Specificity Non-error rate Accuracy MCC* AUC
Training/cross validation/test Training/cross validation/test Training/cross validation/test Training/cross validation/test Training/cross validation/test Training/cross validation/test
CDK1
 SKN Active 0.888/0.789/0.756 0.896/0.780/0.763 0.869/0.753/0.743 0.882/0.776/0.753 0.884/0.778/0.753 0.766/0.506/0.612 0.88
Inactive 0.878/0.764/0.750 0.869/0.753/0.743 0.896/0.799/0.763
 CPANN Active 0.858/0.780/0.787 0.918/0.854/0.875 0.824/0.721/0.752 0.871/0.788/0.814 0.875/0.793/0.815 0.749/0.583/0.633 0.96
Inactive 0.896/0.810/0.851 0.825/0.721/0.752 0.918/0.854/0.875
CDK2
 SKN Active 0.943/0.872/0.872 0.960/0.898/0.915 0.895/0.762/0.775 0.928/0.830/0.845 0.937/0.849/0.862 0.863/0.669/0.703 0.93
Inactive 0.927/0.805/0.845 0.895/0.762/0.775 0.961/0.898/0.915
 CPANN Active 0.900/0.850/0.865 0.951/0.907/0.905 0.808/0.711/0.763 0.880/0.810/0.834 0.900/0.837/0.852 0.780/0.650/0.680 0.97
Inactive 0.901/0810/0.828 0.808/0.711/0.763 0.951/0.907/0.905
CDK4
 SKN Active 0.966/0.946/0.947 0.977/0.959/0.976 0.893/0.826/0.844 0.935/0.893/0.910 0.957/0.927/0.942 0.881/0.800/0.847 0.94
Inactive 0.926/0.866/0.927 0.893/0.826/0.844 0.977/0.959/0.976
 CPANN Active 0.952/0.936/0.929 0.977/0.957/0.965 0.846/0.795/0.788 0.912/0.876/0.877 0.945/0.918/0.919 0.849/0.797/0.784 0.99
Inactive 0.922/0.857/0.887 0.846/0.795/0.788 0.977/0.957/0.965
CDK5
 SKN Active 0.826/0.737/0.683 0.914/0.827/0.833 0.894/0.837/0.795 0.904/0.832/0.814 0.901/0.834/0.808 0.792/0.650/0.605 0.97
Inactive 0.950/0.898/0.900 0.894/0.837/0.795 0.914/0.827/0.833
 CPANN Active 0.825/0.741/0.672 0.921/0.807/0.781 0.893/0.845/0.798 0.907/0.826/0.789 0.903/0.831/0.792 0.796/0.641/0.562 0.97
Inactive 0.953/0.888/0.873 0.893/0.845/0.798 0.921/0.807/0.781
CDK9
 SKN Active 0.931/0.904/0.875 0.946/0.908/0.886 0.849/0.791/0.733 0.897/0.849/0.809 0.915/0.871/0.837 0.803/0.701/0.624 0.90
Inactive 0.879/0.799/0.754 0.849/0.791/0.733 0.946/0.908/0.886
 CPANN Active 0.927/0.888/0.876 0.969/0.929/0.897 0.835/0.747/0.733 0.902/0.838/0.815 0.927/0.872/0.844 0.829/0.697/0.639 0.98