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. 2024 Jul 3;7:806. doi: 10.1038/s42003-024-06447-4

Fig. 4. Impairment of the late phase of CF elimination mediated by mGlu1 in PCs in cerebellar lobules 8-9 of TARPγ2-GC-KO mice.

Fig. 4

a–d Developmental changes in CF innervation. Frequency distribution histograms of PCs in terms of the number of discrete CF-EPSC steps during P6–P8 (a), P10–P12 (b), P13–P15 (c), and P16–P18 (d) in cerebellar lobules 8-9 from control (white columns) and TARPγ2-GC-KO (red columns) mice. *P < 0.05, Mann-Whitney U test. e, f CF innervation in adult PCs. Frequency distribution histograms of PCs in terms of the number of discrete CF-EPSC steps during P60-P80 in cerebellar lobules 8-9 (e) and 1-4/5 (f) from control (white columns) and TARPγ2-GC-KO (red columns) mice. ***P < 0.001, Mann-Whitney U test. g–j Occlusion of impaired CF synapse elimination by mGlu1 knockdown in PCs of TARPγ2-GC-KO mice. Sample CF-EPSC traces (g, i) and frequency distribution histograms in terms of the number of discrete CF-EPSC steps (h, j) for mGlu1 knockdown in PCs of control mice aged P21 to P37 (g, h) and TARPγ2-GC-KO aged P22 to P34 (i, j). Holding potentials for (g, i), − 10 mV. Scale bars for g, i, 10 ms, and 0.5 nA. *P < 0.05, Mann-Whitney U test.