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. 2024 Jul 3;14:15307. doi: 10.1038/s41598-024-65969-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Prognostic significance of PSA doubling time (PSADT) cut-off derived by survival tree. (A) Overall survival (OS), and (B) cancer-specific survival (CSS) of nmCRPC patients with PSADT cut-offs of < 4.65 months and ≥ 4.65 months were analyzed by Kaplan–Meier method. (C) Progression-free survival (PFS) and (D) time to second progression or death (PFS2) of nmCRPC patients with PSADT cut-offs of < 2.85 months and ≥ 2.85 months were analyzed by Kaplan–Meier method. Statistical significance was evaluated by log-rank test. Hazard risk (HR) was evaluated by proportional hazard model.