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. 2024 Jul 4;10:129. doi: 10.1038/s41531-024-00738-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–d In the streamlined SAA reactions, skin homogenates from both PD patients and HC were subjected to analysis. The seeding activity of αSynD was detected in all 20/20 skin samples from PD patients at DTS-lab and 19/20 of the same PD patients at YX-lab (a and b). Conversely, none of the samples from HC induced seeding activity at YX-lab, while 1/12 skin samples from HC exhibited seeding activity at DTS-lab (c and d). The curves depicted in the graphs were generated by plotting the average fluorescence intensities of each sample over time.