Table 1.
Demographic characteristics of patients at baseline and follow up
| Parameters | Baseline (n = 59), n (%) | Follow-up (n = 27), n (%) |
|---|---|---|
| Age in years | 64.3 (9.1)* | |
| Male gender | 56 (94.9) | |
| ECOG status | ||
| 0–1 | 33 (55.9) | 18 (66.7) |
| 2–4 | 26 (44.1) | 09 (33.3) |
| KPS | ||
| 90–100 | 20 (33.9) | 13 (48.1) |
| 80 and below | 39 (66.1) | 14 (51.9) |
| Smoking status | ||
| Never smoker | 02 (3.4) | |
| Current smoker | 52 (88.1) | |
| Former smoker | 05 (8.5) | |
| Smoking index | 551.8 (376.4)* | |
| Comorbidities | 25 (42.4) | |
| TNM stage | ||
| IIIB | 16 (27.1) | |
| IIIC | 08 (13.6) | |
| IVA | 30 (50.8) | |
| IVB | 05 (8.5) | |
| RSB score | 9.9 (5.8)* | 4.1 (4.5)* |
| TSB score | 16.9 (9.9)* | 8.2 (8.0)* |
| cfDNA detectability | 13 (22.0) | 18 (66.7) |
| cfDNA levels (pg/μL) | 77.3 (181.3)* | 244.3 (279.8)* |
| RECIST 1.1 change | ||
| PR | 18 (66.7) | |
| SD | 05 (18.5) | |
| PD | 4 (14.8) | |
* Data represented as mean (StdDev). Current smoker: smoked cigarettes/bidis within the last 6 months; never smoker: smoked less than 100 cigarettes in his/her lifetime; former smoker: smoked cigarettes/bidis before 6 months; KPS: Karnofsky performance scale; PR: partial response; SD: stable disease; PD: progressive disease; ECOG: Eastern Co-operative Oncology Group; TNM: tumor-nodes-metastasis; RSB: respiratory symptom burden; TSB: total symptom burden; cfDNA: cell free DNA; RECIST: response evaluation criteria in solid tumours