Figure 3.

(A) LD Plot of P2RX7. The display was performed according to the Broad Institute’s Standard Color Scheme. The number in the boxes refers to the coefficient D’. SNPs that showed associations with pneumonia and/or sepsis are in red. (B) Structure of the P2RX7 gene with the location of studied SNPs. SNPs with statistically significant results in the current study are highlighted red, SNPs being part of the SNP combination model are highlighted in grey boxes. (C) Illustration of two important SNP combinations related to survival, filled symbols indicate heterozygosity and open symbols indicate wildtype genotypes of the respective SNP. (D) Distribution of patients with sepsis with and without pneumonia, who survived/died and their corresponding P2RX7 SNP combinations as defined in a previous study (17).