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. 2024 Jun 12;8(8):bvae114. doi: 10.1210/jendso/bvae114

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms.

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Figure 3. — Expression profile of differentially expressed miRNAs among T2D − DN and T2D + DN. (A-C) Expression of differentially expressed miRNAs miR-1307, miR-320a, and miR-423-5p by signal values between healthy, type 2 diabetes without nephropathy (T2D − DN) and type 2 diabetes with nephropathy (T2D + DN) patients. (D-F) Box plot shows the expression of differentially expressed miRNAs (miR-1307, miR-320a, and miR-423-5p) by signal values between T2D + DN and T2D − DN patients with normal individual (ACR < 30 mg/g), microalbuminuria (30 < ACR < 300), and macroalbuminuria (ACR > 300 mg/g). (G-I) ROC curves for miR-1307, miR-320a, and miR-423-5p of T2D − DN vs heathy, T2D + DN vs healthy, and T2D + DN vs T2D − DN. The area under the ROC curve (AUC) represents the accuracy of the miR-1307, miR-320a, and miR-423-5p biomarkers in T2D − DN and T2D + DN. *indicates P < .05, **indicates P < .01, ***indicates P < .001 and “ns” indicates not significant.