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. 2024 Jun 12;8(8):bvae114. doi: 10.1210/jendso/bvae114

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. See the journal About page for additional terms.

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Figure 4. — Prediction of target genes of ECV miRNAs, functions, and pathways of differentially expressed miRNAs. (A) mRNA-miRNA target interaction network obtained from a list of shared DE-miRNAs among type 2 diabetes with nephropathy (T2D + DN) and type 2 diabetes without nephropathy (T2D − DN). The network contains the significant T2D + DN and T2D − DN related miRNA-mRNA target interactions network retrieved from MIENTURNET. The miRNA is represented by red triangular shape nodes and mRNA by cyan color circular shape nodes; the green color nodes are genes targeted by prognostic miR (miR-151a and miR-182-5p) (B) Significant enriched biological process of shared DE-miRNA in T2D + DN and T2D − DN. Dot size indicates count. Count represents the number of genes associated with each pathway. Dot color denotes the P values of pathways and x-axis represent fold enrichment. (C) Bar plot of significant biological pathways of predicted genes of shared DE-miRNA in T2D + DN and T2D − DN patients. X-axes represent count of genes with significance (P < .05) indicated by order and color trend. (D) mRNA-miRNA core network module of driver genes and key DE-miRNAs.