Table 4.
Significant shared differentially expressed urinary extracellular vesicular miRNAs in type 2 diabetes without nephropathy (T2D − DN) vs healthy and type 2 diabetes with nephropathy (T2D + DN) vs healthy
| (T2D − DN vs healthy) | (T2D + DN vs healthy) | ||||
|---|---|---|---|---|---|
| S. No. | DE-miRNA | Fold change | P value | Fold change | P value |
| 1. | hsa-miR-107 | −5.02 | .000007 | −3.31 | .006926 |
| 2. | hsa-miR-148b-3p | −3.01 | .001775 | −2.91 | .015193 |
| 3. | hsa-miR-203a-3p | −2.3 | .004299 | −2.37 | .021347 |
| 4. | hsa-miR-205-5p | −2.9 | .000167 | −6.32 | .00000009 |
| 5. | hsa-miR-26a-5p | −1.95 | .013386 | −1.92 | .042271 |
| 6. | hsa-miR-30c-5p | −3.39 | .001962 | −2.26 | .000437 |
| 7. | hsa-miR-361-3p | −3.92 | .001452 | −3.37 | .021368 |
| 8. | hsa-miR-361-5p | −3.56 | .005946 | −2.95 | .01126 |
| 9. | hsa-miR-660-5p | −2.75 | .045127 | −1.83 | .009273 |
| 10. | hsa-miR-1246 | 11.6 | .0000004 | 5.69 | .000218 |
| 11. | hsa-miR-1307-3p | 2.71 | .000979 | 6.15 | .0000001 |
| 12. | hsa-miR-151a-3p | −1.8 | .0026164 | 2.17 | .0011401 |
| 13. | hsa-miR-182-5p | −2.96 | .000663 | 3.53 | .000516 |
| 14. | hsa-miR-196a-5p | 3.2 | .000931 | 3.79 | .011608 |
| 15. | hsa-miR-204-3p | 8.63 | .010186 | 9.51 | .011607 |
| 16. | hsa-miR-320a | 2.84 | .000116 | 5.34 | .0000005 |
| 17. | hsa-miR-320b | 4.94 | .00002 | 6.14 | .000538 |
| 18. | hsa-miR-320c | 6.19 | .0000067 | 10.14 | .00002 |
| 19. | hsa-miR-378a-3p | 3.97 | .0000029 | 2.61 | .002763 |
| 20. | hsa-miR-378c | 3.44 | .0000035 | 7.46 | .007745 |
| 21. | hsa-miR-423-3p | 3.29 | .003931 | 3.93 | .00347 |
| 22. | hsa-miR-423-5p | 2.15 | .003986 | 4.44 | .000001 |
| 23. | hsa-miR-4532 | 6.39 | .000175 | 3.28 | .02217 |
| 24. | hsa-miR-664a-5p | 2.78 | .032326 | 5.61 | .001117 |
| 25. | hsa-miR-671-5p | 9.64 | .0000008 | 11.24 | .00000017 |