Figure 2.

CDKN2A copy number status in bladder tumors

(A–C) Boxplots presenting the correlation of CDKN2A copy number loss (HD/LOH) with mRNA expression across PDX samples (A), mRNA and protein levels in the TCGA-BLCA cohort (B), and mRNA levels in the Lindgren et al. cohort (C). The p values were calculated by Mann-Whitney U (A) and Kruskal-Wallis (B and C) tests. (D and E) Kaplan-Meier survival curves of PDX mouse models according to CDKN2A copy number status (D) and CDKN2A mRNA levels (E). The p value was calculated by log rank test. (F) Bar graphs of CDKN2A copy number status distribution across the molecular subtypes (consensusMIBC 2020) of the TCGA-BLCA cohort. The p values were evaluated by Fisher’s exact test. (G) Boxplots presenting the correlation of CDKN2A expression between LumP vs. other subtypes and LumP vs. Ba/Sq subtypes. The p values were calculated by Mann-Whitney U test.