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. 2024 May 24;32(2):200818. doi: 10.1016/j.omton.2024.200818

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© 2024 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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High CDKN2A index in pre-treatment cfDNA is associated with worse prognosis

(A–D) Boxplots presenting the correlation of the CDKN2A index in pre-treatment cfDNA with patient tumor stage (A and B) and grade (C and D). The p values (two-sided) were calculated by Mann-Whitney U (A and C) and Kruskal-Wallis (B and D) tests. (E) Kaplan-Meier survival curve for the PFS of the NMIBC cohort according to CDKN2A index in pre-treatment cfDNA. The p value was calculated by log rank test. (F and G) Forest plots of the univariate and multivariate Cox regression analysis for the PFS of NMIBC patients. Internal validation was performed by bootstrap Cox proportional regression analysis based on 1,000 bootstrap samples.