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Study schedule of visits, and sampling of upfront cytoreductive nephrectomy group (Group A)
| Time | 0 | X | X + 4 months | X + 7 months |
|---|---|---|---|---|
| Visit | Baseline visit | During surgery | After ICI induction phase (4 cycles) | After ICI maintenance phase (6 cycles) |
| Blood sample | O | O | O | O |
| Urine sample | O | O | O | O |
| Stool sample | O | O | O | O |
| Tumor tissue sample | O | O |
