Table 2:
Cross-sectional associations between later-life (visit 5) lung function measures and later-life (visit 5) brain MRI outcomes in the Atherosclerosis Risk in Communities Neurocognitive Study (n=1223)
| FEV1 (per 1L) | FVC (per 1L) | FEV1/FVC (per 1%) | |
|---|---|---|---|
| MRI outcomes | Beta (95% CI) | Beta (95% CI) | Beta (95% CI) |
| Brain volume (cm3)a | |||
| Total braina | 8.62 (2.54, 14.71) | 10.00 (4.80, 15.20) | −0.11 (−0.42, 0.19) |
| Frontal lobea | 1.53 (0.33, 2.73) | 1.27 (0.24, 2.30) | 0.03 (−0.03, 0.09) |
| Temporal lobea | 1.47 (0.56, 2.39) | 1.15 (0.37, 1.94) | 0.02 (−0.02, 0.07) |
| Occipital lobea | 0.38 (−0.11, 0.87) | 0.34 (−0.08, 0.76) | −0.00 (−0.03, 0.02) |
| Parietal lobea | 1.03 (0.13, 1.94) | 0.98 (0.20, 1.76) | 0.01 (−0.04, 0.05) |
| Deep gray mattera | 0.42 (0.05, 0.79) | 0.30 (−0.02, 0.62) | 0.01 (−0.01, 0.03) |
| Temporal-parietal lobe meta ROIa | 0.80 (0.26, 1.35) | 0.65 (0.18, 1.12) | 0.01 (−0.02, 0.04) |
| WMH volume (natural log-cm3)a | −0.12 (−0.22, −0.02) | −0.14 (−0.23, −0.05) | 0.00 (−0.00, 0.01) |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| Microbleedsb | 1.06 (0.77, 1.47) | 1.02 (0.77, 1.34) | 1.01 (0.99, 1.02) |
| Infarctsb | 0.81 (0.59, 1.12) | 0.84 (0.64, 1.11) | 1.00 (0.98, 1.02) |
Note: CI, Confidence Intervals; FEV1, Forced Expiratory Volume in one second; FVC, Forced Vital Capacity; MRI, Magnetic Resonance Imaging; OR, Odds Ratio; ROI, Regions of Interest; WMH, White Matter Hyperintensity
Linear regression models were used for the continuous outcomes (i.e., brain and WMH volumes).
Logistic regression models were used for the dichotomous outcomes (i.e., microbleeds and infarcts).
Models were adjusted for age, sex, education, center-race, smoking status, height, weight, physical activity, diabetes, prevalent coronary heart disease, hypertension status, total cholesterol, APOE ε4 carrier status, and total estimated intracranial volume.
FEV1, FVC, and FEV1/FVC were modeled separately.