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. 2024 Jun 17;9(26):29053–29068. doi: 10.1021/acsomega.4c04483

Table 2. Box–Behnken Factorial Design with the Independent Variables and Experimental and Predicted TPC Values in Aqueous Olive Tree L. Extracta.

run coded variable
actual variable
TPC [μg GAE/mL]
  x1 [g/mL] x2 [°C] x3 [min] X1 [g/mL] X2 [°C] X3 [min] actual predicted residual
1 –1 –1 0 0.008 50 70 97.13 94.96 2.17
2 1 –1 0 0.016 50 70 121.47 121.67 –0.20
3 –1 1 0 0.008 90 70 133.47 133.27 0.20
4 1 1 0 0.016 90 70 156.00 158.17 0.10
5 –1 0 –1 0.008 70 50 109.13 108.89 0.12
6 1 0 –1 0.016 70 50 139.80 137.20 –2,17
7 –1 0 1 0.008 70 90 126.23 128.84 –2.61
8 1 0 1 0.016 70 90 151.90 152.14 –0.24
9 0 –1 –1 0.012 50 50 93.23 95.64 –2,41
10 0 1 –1 0.012 90 50 134.23 134.66 –0.43
11 0 –1 1 0.012 50 90 115.13 114.70 0.43
12 0 1 1 0.012 90 90 152.90 150.49 2.41
13 0 0 0 0.012 70 70 143.90 143.30 0.30
14 0 0 0 0.012 70 70 144.13 143.30 0.83
15 0 0 0 0.012 70 70 143.33 143.30 0.03
16 0 0 0 0.012 70 70 142.67 143.30 –0.63
17 0 0 0 0.012 70 70 142.47 143.30 –0.83
a

Note: x1 and X1—biomass weight/extraction solvent ratio, x2 and X2—extraction temperature [°C], and x3 and X3—extraction time [min].