Table 2.

Expression patterns of E-cadherin in normal oral mucosa, oral epithelial dysplasia, and oral squamous cell carcinoma

Beta-catenin expression42,52,54,58,61,63–66	NOM	OED	OSCC
Cell membrane	High	Decreaseda	Decreaseda
Cytoplasm	None (Kaur et al.54 and Ishida et al.42 indicate minimal expression)	Increaseda	Increaseda (Mixed results when comparing expression in OSCC to OED)
Nucleus	None (Kaur et al.54 indicate minimal expression)	Increaseda (Especially in severe OED – Chaw et al.,58 Reyes et al.,64 Lo Muzio et al.65)	Increaseda (Mixed results when comparing expression between OSCC and OED)

NOM: normal oral mucosa; OED: oral epithelial dysplasia; OSCC: oral squamous cell carcinoma

^acompared to NOM

Adapted from Yim⁵³