Table 2.
Warfarin dosing and prothrombin values
| Subject | Five Days Prior to Treatment |
Day of Treatment | Day of Necropsy | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PT (sec) |
Dose (mg/kg) |
PT (sec) |
Δ PT from baseline |
Dose (mg/kg) |
Δ Dose from baseline (mg/kg) |
PT (sec) |
Δ PT from baseline |
Dose (mg/kg) |
Δ Dose from treatment (mg/kg) |
|
| 1 | 15.3 | 0.08 | 25.4** | 66.0% | 0.04 | −0.02 | 20.7* | 35.3% | 0.04 | 0 |
| 2 | 17.3 | 0.08 | 22.5* | 30.1% | 0.07 | 0.01 | 34.3** | 98.3% | 0.07 | 0 |
| 3 | 15.5 | 0.08 | 18.3 | 18.1% | 0.08 | 0.02 | 27.2** | 75.5% | 0.07 | −0.01 |
| 4 | 15.1 | 0.08 | 17.4 | 15.2% | 0.08 | 0.02 | 22.3* | 47.7% | 0.07 | −0.01 |
| 5 | 17.0 | 0.08 | 16.1 | −5.3% | 0.08 | 0.02 | 28.5** | 67.6% | 0.08 | 0 |
| 6 | 17.1 | 0.08 | 24.9* | 45.6% | 0.06 | 0.00 | 49.6** | 190.1% | 0.06 | 0 |
| 7 | 15.3 | 0.08 | 29.8** | 94.8% | 0.04 | −0.02 | 23.5** | 53.6% | 0.04 | 0 |
| 8 | 15.7 | 0.08 | 21.3* | 35.7% | 0.06 | 0 | 24.2** | 54.1% | 0.06 | 0 |
| Mean | 16.0 | 0.08 | 22.0* | 37.5% | 0.06 | 0.00 | 28.8** | 77.8% | 0.06 | 0.00 |
PT = prothrombin time
*
indicates the subject was at a therapeutic level of anticoagulation (30-50% Δ PT from baseline)
**
indicates supra-therapeutic level of anticoagulation (>50% Δ PT from baseline)