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. 2024 Jul 4;2024:baae055. doi: 10.1093/database/baae055

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© The Author(s) 2024. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Alt text: (A) Bar chart: 1697 showed full consensus; 772, 405 and 84 showed discrepancies according to the 5-tier, 3-tier and 2-tier models, respectively. (B) Bar chart: 33, 18 and 4 variants showed discrepancies after phases 1, 2 and 3, respectively. — (A) Variants with multiple classifications in SpadaHC v1.21.0 and degree of discrepancy according to the five-tier, three-tier and two-tier models. (B) Number of variants with clinically relevant discrepancies according to the two-tier model after each phase of the resolution strategy.