REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Bacterial and virus strains
E. Coli: OP50	Caenorhabditis Genetics Center	OP50
E. Coli: HT115	Caenorhabditis Genetics Center	HT115
Biological samples
Chemicals, peptides, and recombinant proteins
2-Butanone, 99+%, extra pure	Acros Organics	Cat# 149670250
Critical commercial assays
Deposited data
Human brain bulk RNA sequencing data	(Wang et al., 2018)	Synapse: syn3159438; https://www.synapse.org/#!Synapse:syn3159438
Human brain single-nucleus RNA sequencing data	(Cain et al., 2023)	Synapse: syn16780177; https://www.synapse.org/#!Synapse:syn16780177
Experimental models: Cell lines
Experimental models: Organisms/strains
C. elegans strain LC108: vIs69 [pCFJ90(Pmyo-2::mCherry + Punc-119::sid-1)]	Caenorhabditis Genetics Center	LC108
Oligonucleotides
Recombinant DNA
Plasmid: pL4440 RNAi control	Ahringer RNAi library	N/A
Plasmid: pL4440-vha-10 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-jnk-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-aps-2 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-zyg-9 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-F54A3.2 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-cmd-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-apl-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-Y62E10A.2 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-ephx-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-misc-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-pho-5 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-pho-14 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-mtch-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-nuo-2 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-rpt-5 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-amph-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-unc-11 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-rpy-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-nmr-2 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-gpb-1 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-gtl-2 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-lad-2 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-T09B9.3 RNAi	Ahringer RNAi library	N/A
Plasmid: pL4440-nhr-23 RNAi	Ahringer RNAi library	N/A
Software and algorithms
WGCNA v1.70.3	(Langfelder and Horvath, 2008)	https://horvath.genetics.ucla.edu/html/CoexpressionNetwork/Rpackages/WGCNA/
R version 4.0.5	R Core Team	https://www.R-project.org/
Rstudio v1.4	R Studio	https://rstudio.com/products/rstudio/
Seurat v4.1.0	(Hao et al., 2021)	https://satijalab.org/seurat/index.html/
Prism 8	Graphpad Prism	https://www.graphpad.com/scientific-software/prism/
Other