Figure 7.

Signal transduction activity of somatostatin receptors induced by an SSTR agonist and native SST peptides. COS‐7 cells were co‐transfected with Cre‐luc plasmid and either SSTR2a (A), SSTR3a (B), SSTR5b (C), or SSTR3b (D). Transfected cells were exposed to increasing concentrations of octreotide (an SST agonist) or somatostatin peptides SST6 or SST3 (0–1000 nM) in combination with FSK (20 μM). Graphs show fold changes in luciferase activity relative to the basal level. Averaged data from three experiments are shown and are presented as mean ± SEM. Asterisk-marked points significantly differ from basal levels: *p < 0.05; **p < 0.01, (one-way ANOVA followed by Dunnett’s test).