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The effect of cyclosomatostatin and octreotide on tilapia SST receptors.
| SST-R2a | SST-R3a | SST-R5b | SST-R3b | ||
|---|---|---|---|---|---|
|
Cyclosomatostatin
(SSTR antagonist) |
EC50 (nM) | 188.90 ± 4.34 | 0.10± 0.001 | 2.15 ± 0.009 | 46.21 ± 3.82 |
|
Octreotide
(SSTR agonist) |
IC50 (nM) | 0.81 ± 0.01 | 8.6x10-4 ± 0.0007 | 17.36 ± 3.14 | 0.35 ± 0.04 |
Cre-luciferase was used to assess PKA activation. Results are shown as mean ± SEM.
