Table 4.
Results of the repeated measure analyses of (co)variance investigating group (responder versus non-responder) and time differences (measurement time 1 versus measurement time 2) regarding kynurenine, its downstream metabolite levels, and their ratios over time.
| Main effect group | Main effect time | Interaction effect group x time | |||||
|---|---|---|---|---|---|---|---|
| F | η² | F | η² | F | η² | df | |
| KYNa | 0.06 | .00 | 1.49 | .02 | 7.62* | .09 | 1, 80 |
| XA | 2.46 | .03 | .01 | .00 | 1.48 | .02 | 1, 75 |
| KYNA | 0.74 | .01 | 0.17 | .00 | 0.74 | .01 | 1, 81 |
| 3-HAAb | 10.63** | .13 | 4.58* | .06 | 1.57 | .02 | 1, 74 |
| NA | 4.74* | .06 | 4.80* | .06 | 0.22 | .00 | 1, 77 |
| PA | 0.05 | .00 | 0.03 | .00 | 0.31 | .00 | 1, 81 |
| QA | 0.15 | .00 | 2.84 | .03 | 3.46 | .04 | 1, 81 |
| AAc | 0.94 | .01 | 1.48 | .02 | 1.86 | .03 | 1, 70 |
| 3-HK | 1.22 | .02 | 0.00 | .00 | 0.14 | .00 | 1, 81 |
| 3-HK/KYN | 1.37 | 0.02 | 1.64 | .02 | 5.38* | .06 | 1, 81 |
| 3-HK/KYNA | 0.64 | .01 | 0.15 | .00 | 1.72 | .02 | 1, 81 |
| KYNA/KYN | 0.18 | .00 | 2.29 | .03 | 1.15 | .01 | 1, 81 |
| KYNA/QA | 0.93 | .01 | 0.07 | .00 | 0.01 | .00 | 1, 81 |
| 3-HAA/KYN | 4.70* | .06 | 0.48 | .01 | 0.15 | .00 | 1, 74 |
| AA/KYN c | 1.01 | .01 | 1.91 | .02 | 1.34 | .00 | 1, 70 |
KYN, Kynurenine; XA, Xanthurenic Acid; KYNA, Kynurenic acid; 3-HAA, 3-Hydroxyanthranilic acid; NA, Nicotinic acid; PA, Picolinic acid; QA, Quinolinic acid; AA, Anthralinic acid; 3-HK, 3-Hydroxykynurenine; 3-HK/KYN ratio, 3-Hydroxykynurenine/kynurenine; 3-HK/KYNA ratio, 3-Hydroxykynurenine/kynurenic acid; KYNA/ KYN ratio, Kynurenic acid/kynurenine; KYNA/QA ratio, Kynurenine/quinolinic acid; 3-HAA/KYN ratio, 3-Hydroxyanthranilic acid/kynurenine; AA/KYN, Anthralinic acid/kynurenine. Significant results are printed in bold. *p < .05 **p < .01. aAnalysis included the covariate Body Mass Index. bVariable transformed using the logarithmic transformation due to violation of homogeneity of variance. cVariable transformed using the reciprocal transformation due to violation of homogeneity of variance.