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. 2024 Jun 21;15:1424765. doi: 10.3389/fphar.2024.1424765

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Copyright © 2024 Yang, Wang, Zhao, Zhang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Features of Nanotechnology in Improving Polymyxin Resistance. Nanotechnology has emerged as a cornerstone in the battle against antibiotic resistance. Nano-carriers bolster the resilience of antibiotics amidst the intricacies of physiopathological landscapes. Harnessing the potential of gels and polymer nanofibers, the longevity of antibiotic release is notably augmented. Moreover, these carriers adeptly prolong the drug’s residence at injury locales. Their biodegradable and non-invasive nature ensures a harmonious interaction with the human physiology. These nano-carriers deftly modulate drug release within the gastrointestinal milieu, optimizing absorption and maximizing bioavailability. Beyond that, the strategic design of nanoparticles and microparticles ensures a precision-guided delivery to infection epicentres, adeptly curbing side effects and magnifying therapeutic efficacy.