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. 2024 Jun 21;15:1424765. doi: 10.3389/fphar.2024.1424765

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Copyright © 2024 Yang, Wang, Zhao, Zhang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparative Pharmacokinetic Profiles of PMB and Colistin. This flowchart elucidates the distinct pharmacokinetic properties of PMB and Colistin. For PMB, the diagram underscores its distribution, half-life, and excretion pathways, notably the minimal renal excretion and a potential route through biliary excretion. In contrast, colistin is emphasized for its intravenous administration as the inactive prodrug, colistin methanesulphonate. The recommended concentrations for both drugs are depicted, with an accent on potential side effects, especially the heightened risk of nephrotoxicity when exceeding the advised levels.