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. 2024 Jun 21;15:1424765. doi: 10.3389/fphar.2024.1424765

TABLE 2.

Clinical trial of polymyxin involved in drug resistance.

Status ClinicalTrials.gov identifier Condition or disease Drug Combination of drugs
Phase 3 NCT03159078 Trauma Polymyxin B Carbapenem
Resistant Infection
Critical Illness
Phase 3 NCT02134106 Bacteremia Polymyxin B Doripenem
Healthcare-associated Pneumonia
Ventilator-associated Pneumonia
Completed NCT00753558 Carriage of Carbapemen-resistant Klebsiella pneumoniae polymyxin E Oral solution and buccal gel of gentamicin
Recruiting NCT04839653 Respiratory Tract Infections polymyxin B Gentamycin, amphotericine B
Critical Illness
Phase 4 NCT04489459 Blood Stream Infections Due to MDR Klebsiella pneumoniae Colistin Meropenem, Tigecycline
Completed NCT01266499 Klebsiella Pneumoniae Carbapenemase Resistant Associated Bacteremia or Pneumonia Colistin Garamycin
Early Phase 1 NCT03950544 Antibiotic-Resistant Infection Polymyxin B Fosfomycin, Tigecycline
Recruiting NCT04202861 Antibiotic Therapy Polymyxins Antibiotic combination
Phase 3 NCT05258851 Carbapenem-Resistant Enterobacteriaceae Infection Colistin Ceftazidime-avibactam
Phase 2 NCT02472600 Intestinal Colonization With MDR Bacteria Colistin Neomycin; Fecal microbiota transplantation; Omeprazole