Figure 2.

Images displaying distal limbs and muscle MRI from families with RTN2-related distal hereditary motor neuropathy. Muscle weakness and wasting of the distal lower > upper limbs in affected individuals from Families 1 (A–F and M–R), 2 (G) and 3 (H–L). Axial fat T1-weighted images of the lower limbs in a 17-year-old Iranian boy [A(i and ii)] and his 27-year-old sister from Family 1 [A(iii and iv)]. The thigh muscles of the boy are normal [A(i)]. There is fatty infiltration of his leg muscles with relative sparing of the medial head of gastrocnemius and extensor digitorum longus [A(ii)]. Changes are more severe in his older sister with generalized loss of muscle bulk and fatty infiltration of the hamstrings [A(iii)]. There is more extensive change in her legs, with relative sparing of the medial head of the gastrocnemius, tibialis anterior, extensor digitorum longus and peroneus longus [A(iv)].