Table 1.

Summary of participant demographics

	Healthy controls	Huntington’s disease	Group difference
n	22	17	N/A
Age, years	50.9 (11.2) [28–65]	53.3 (10.3) [28–65]	P = 0.49
Gender, male:female	12:10	12:5	P = 0.31
Apathy Evaluation Scalea	10.8 (5.89)	15.5 (9.85)	P = 0.09
Dimensional Apathy Scale, Totalb	22.7 (7.12)	36.0 (10.8)	P < 0.001*
Executive	5.71 (3.77)	12.9 (5.94)	P < 0.001*
Initiation	8.62 (3.07)	12.1 (4.59)	P = 0.01*
Emotional	8.38 (3.02)	11.1 (3.72)	P = 0.03*
Hospital Anxiety and Depression Scalec
Anxiety	5.33 (3.44)	5.18 (3.34)	P = 0.89
Depression	3.10 (2.68)	5.71 (4.18)	P = 0.03*
Montreal Cognitive Assessmentd	27.0 (2.01)	23.6 (2.83)	P < 0.001*
Hopkins Verbal Learning Test Revised
Total Recall	26.9 (3.10)	17.0 (4.54)	P < 0.001*
Delayed Recall	9.6 (1.93)	4.71 (2.73)	P < 0.001*
Discrimination Index	11.1 (1.97)	8.13 (3.26)	P = 0.004*
Symbol Digit Modalities Test	58.8 (12.6)	26.6 (9.27)	P < 0.001*
Tapping (mean intertap interval, ms)29
Speeded	195.1 (34.2)	347.4 (85.2)	P < 0.001*
Paced	39.0 (13.5)	216.7 (243.8)	P = 0.01*
CAG repeats	N/A	43.4 (3.02) [41–54]	N/A
Total functional capacity
Self-rated	N/A	8.59 (2.27) [6–13]	N/A
Informant	N/A	8.64 (2.20) [5–13]	N/A
Disease Burden Score30	N/A	399.8 (85.5) [192.5–518]	N/A

Data are presented as means (SD) [range]. N/A = not applicable.

^aRange from 18 to 72. Proposed cut-off scores for apathy in Huntington’s disease are >40 (Naarding et al.³¹) and >41 (Skvortsova et al.³²).

^bProposed cut-off score for apathy ≥38.¹⁹

^cSubscale cut-off of 8.³³

^dCut-off <26.

^*Statistically significant, P < 0.05.