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. 2024 Feb 7;147(7):2414–2427. doi: 10.1093/brain/awae032

Figure 2.

Figure 2

Diagnostic accuracy of SNAP-25, neurogranin, 14-3-3 zeta/delta (ζ/d), β-synuclein and NPTX2. Receiver operating curves calculated for (A) controls (amyloid-β-negative cognitively unimpaired, Aβ− CU) versus preclinical Alzheimer’s disease (AD) (amyloid-β-negative cognitively unimpaired, Aβ+ CU), (B) Aβ− CU versus prodromal AD (Aβ+ MCI), (C) Aβ− CU versus Alzheimer's disease dementia (ADD), (D) ADD versus non-AD neurodegenerative disease (non-AD), (E) Aβ+ CU versus ADD and (F) Aβ− CU versus non-AD for the five synaptic proteins. For the analysis, the NPTX2 levels were inverted. CI = confidence interval.