Table 3. Examples of completed and active clinical trials using second-generation HIV-1bnAbs for the prevention of HIV-1.

CLINICAL TRIAL IDENTIFIER	BROADLY NEUTRALIZING ANTIBODIES	ENVELOPE BINDING SITE
COMPLETED
NCT02568215	VRC01	CD4bs
NCT02716675	VRC01	CD4bs
NCT02824536	3BNC117 10-1074	CD4bs, V3 glycan supersite
ACTIVE
NCT04408963	CAP256V2LS	V1/V2 Loops