Table 1. Clinicopathologic factors, neoadjuvant therapy, and perioperative outcomes with respect to Siewert classification.
| Variable | All (n=58) | Siewert I (n=19) | Siewert II (n=23) | Siewert III (n=16) | P-value | ||
|---|---|---|---|---|---|---|---|
| Age (yr) | 64 (39–81) | 68 (39–81) | 64 (47–81) | 62 (45–72) | 0.115 | ||
| Sex | 0.490 | ||||||
| Female | 15 (25.9) | 6 (31.6) | 4 (17.4) | 5 (31.3) | |||
| Male | 43 (74.1) | 13 (68.4) | 19 (82.6) | 11 (68.8) | |||
| BMI (kg/m2) | 25.6 (14.3–40.8) | 26.9 (19.2–40.8) | 26.4 (19.5–39.8) | 25.4 (14.3–33) | 0.380 | ||
| Ethnicity‡ | 0.083 | ||||||
| White | 41 (70.7) | 14 (73.7) | 19 (82.6) | 8 (50.0) | |||
| Hispanic | 5 (8.6) | 0 (0.0) | 1 (4.3) | 4 (25.0) | |||
| Asian | 9 (15.5) | 2 (10.5) | 3 (13.0) | 4 (25.0) | |||
| Black/African American | 1 (1.7) | 1 (5.3) | 0 (0.0) | 0 (0.0) | |||
| American Indian | 1 (1.7) | 1 (5.3) | 0 (0.0) | 0 (0.0) | |||
| History of Barrett’s esophagus | 22 (37.9) | 11 (57.9) | 7 (30.4) | 4 (25.0) | 0.086 | ||
| History of Helicobacter pylori | 4 (6.9) | 0 (0.0) | 1 (4.3) | 3 (18.8) | 0.076 | ||
| Documented Siewert classification | 24 (41.4) | 4 (21.1) | 13 (56.5) | 7 (43.8) | 0.066 | ||
| Clinical stage | 0.340 | ||||||
| II | 4 (6.9) | 1 (5.3) | 2 (8.7) | 1 (6.3) | |||
| IIA | 2 | 0 | 1 | 1 | |||
| IIB | 2 | 1 | 1 | 0 | |||
| III | 44 (75.9) | 12 (63.2) | 18 (78.3) | 14 (87.5) | |||
| IVA | 10 (17.2) | 6 (31.6) | 3 (13.0) | 1 (6.3) | |||
| Neoadjuvant therapy | |||||||
| Chemoradiation | 42 (72.4) | 18 (94.7) | 17 (73.9) | 7 (43.8) | 0.003 | ||
| Chemotherapy | 24 (41.4) | 1 (5.3) | 10 (43.5) | 13 (81.3) | <0.001 | ||
| Both† | 8 (13.8) | 0 (0.0) | 4 (17.4) | 4 (25.0) | 0.083 | ||
| Surgical approach | <0.001 | ||||||
| Esophagogastrectomy | 47 (81.0) | 18 (94.7) | 23 (100.0) | 6 (37.5) | |||
| Total gastrectomy | 11 (19.0) | 1 (5.3) | 0 (0.0) | 10 (62.5) | |||
| D2 LN dissection performed | 21 (36.2) | 1 (5.3) | 9 (39.1) | 11 (68.8) | <0.001 | ||
| Pathologic LNs | |||||||
| Positive status | 30 (51.7) | 9 (47.4) | 12 (52.2) | 9 (56.3) | 0.870 | ||
| Total number harvested | 30 [22–38] | 26 [17–32] | 29 [23–34] | 37 [30–50] | 0.027 | ||
| Pathologic stage | 0.742 | ||||||
| I | 23 (39.7) | 8 (42.1) | 8 (34.8) | 7 (43.8) | |||
| II | 9 (15.5) | 2 (10.5) | 3 (13.0) | 4 (25.0) | |||
| III | 22 (37.9) | 7 (36.8) | 10 (43.5) | 5 (31.3) | |||
| IIIA | - | 2 | 3 | - | |||
| IIIB | - | 5 | 7 | - | |||
| IVA | 4 (6.9) | 2 (10.5) | 2 (8.7) | 0 (0.0) | |||
| Histologic type | 0.975 | ||||||
| Intestinal | 36 (64.3) | 12 (63.2) | 14 (63.6) | 10 (66.7) | |||
| Diffuse | 20 (35.7) | 7 (36.8) | 8 (36.4) | 5 (33.3) | |||
| Unknown | 2 | 0 | 1 | 1 | |||
| Pathologic grade | 0.038 | ||||||
| Moderately differentiated* | 19 (33.9) | 2 (10.5) | 9 (39.1) | 8 (50.0) | |||
| Poorly differentiated | 39 (67.2) | 17 (89.5) | 14 (60.9) | 8 (50.0) | |||
| Tumor regression score§ | 0.256 | ||||||
| Complete response | 12 (20.7) | 4 (21.1) | 4 (17.4) | 4 (25.0) | |||
| Near complete response | 12 (20.7) | 5 (26.3) | 4 (17.4) | 3 (18.8) | |||
| Partial response | 25 (43.1) | 8 (42.1) | 13 (56.5) | 4 (25.0) | |||
| Poor or no response | 8 (13.8) | 1 (5.3) | 2 (8.7) | 5 (31.3) | |||
| Recurrence | |||||||
| Any | 29 (50.0) | 9 (47.4) | 15 (65.2) | 5 (31.3) | 0.109 | ||
| Intrathoracic | 14 (24.1) | 3 (15.8) | 10 (43.5) | 1 (6.3) | 0.016 | ||
| Intraabdominal | 20 (34.5) | 5 (26.3) | 10 (43.5) | 5 (31.3) | 0.482 | ||
| Local | 3 (5.2) | 1 (5.3) | 2 (8.7) | 0 (0.0) | 0.483 | ||
| Bone | 4 (6.9) | 2 (10.5) | 1 (4.3) | 1 (6.3) | 0.729 | ||
| Brain | 2 (3.4) | 2 (10.5) | 0 (0.0) | 0 (0.0) | 0.119 | ||
Values are presented as number (%), median (range), or median [interquartile range]. Bold styled P-values indicate statistically significant.
BMI = body mass index; LN = lymph node.
*Includes one patient with well-differentiated pathologic grade.
†Refers to patients receiving both neoadjuvant chemoradiotherapy and full-dose perioperative chemotherapy.
‡A patient in the Siewert I group is missing ethnicity data.
§A patient in the Siewert I group is missing tumor regression score data.