Table 3.
Odds ratios for advanced liver fibrosis, defined as liver stiffness >9.7 kPa,23 according to muscle quality assessed using the zscore of muscle echo-intensity
| Variable | Muscle quality | ||
|---|---|---|---|
| Modest | Intermediate | Poor | |
| All patients | |||
| Model 1 | Ref. | 5.342 (2.432–11.736)* | 7.584 (3.345–17.195)* |
| Model 2 | 5.473 (2.478–12.098)* | 7.985 (3.446–18.502)* | |
| Model 3 | 4.932 (2.154–11.294)* | 7.565 (3.127–18.303)* | |
| Model 4 | 4.898 (2.143–11.194)* | 7.713 (3.190–18.649)* | |
| Model 5 | 4.925 (2.152–11.270)* | 7.634 (3.153–18.487)* | |
| Non-obese patients | |||
| Model 1 | Ref. | 2.312 (0.371–14.390) | 9.878 (1.795–54.366)† |
| Model 2 | 2.376 (0.349–16.157) | 8.959 (1.493–53.743)‡ | |
| Model 3 | 2.539 (0.376–17.172) | 8.623 (1.466–50.705)‡ | |
| Model 4 | 3.017 (0.433–21.040) | 10.579 (1.767–63.337)‡ | |
| Model 5 | 3.412 (0.441–26.373) | 12.259 (1.822–82.478)‡ | |
Values are presented as odds ratio (95% confidence interval). The 307 patients in the entire cohort (143 men and 164 women), which included 98 non-obese patients (45 men and 53 women), were grouped according to tertiles of muscle echo-intensity. Logistic regression was used to evaluate the relationship between muscle echo-intensity tertile z-score and liver stiffness >9.7 kPa, which was used to define advanced liver fibrosis by Lomonaco et al.23 Model 1 was adjusted for age; model 2 was adjusted for age and body mass index; model 3 was adjusted for these variables plus body fat mass; and model 4 was adjusted for these variables plus lean body mass. The ranges of muscle echo-intensity for each tertile were as follows: All patients: modest, 40.8–93.0 arbitrary units (A.U.), intermediate, 93.1–102.2 A.U., poor, 102.2–182.4 A.U.; and nonobese patients: modest, 43.3–92.4 A.U., intermediate, 93.0–105.6 A.U., poor, 105.9–182.4 A.U.
*P<0.001; †P<0.01; ‡P<0.05.