TABLE A2.
Summary of descriptive characteristics for the study population of 2,289 patients and stratified by predominant COVID-19 variant at diagnosis.
| Characteristic | Overall1 n = 2,289 |
Original1 n = 1,528 |
Alpha1 n = 320 |
Delta1 n = 441 |
p-value2 |
|---|---|---|---|---|---|
| Age, years | 61 (43, 72) | 62 (47, 73) | 59 (36, 70) | 59 (38, 72) | <0.001 |
| Sex | 0.8 | ||||
| Female | 938 (41%) | 630 (41%) | 126 (39%) | 182 (41%) | |
| Male | 1,351 (59%) | 898 (59%) | 194 (61%) | 259 (59%) | |
| Race | <0.001 | ||||
| White | 1,610 (70%) | 1,030 (67%) | 229 (72%) | 351 (80%) | |
| Black | 436 (19%) | 326 (21%) | 58 (18%) | 52 (12%) | |
| Other/Unknown | 243 (11%) | 172 (11%) | 33 (10%) | 38 (8.6%) | |
| Ethnicity | 0.9 | ||||
| Hispanic or Latino | 101 (4.4%) | 64 (4.2%) | 15 (4.7%) | 22 (5.0%) | |
| Non-Hispanic or Latino | 2,104 (92%) | 1,409 (92%) | 291 (91%) | 404 (92%) | |
| Refused/Unknown | 84 (3.7%) | 55 (3.6%) | 14 (4.4%) | 15 (3.4%) | |
| Body Mass Index | 29 (24, 34) | 29 (25, 34) | 29 (23, 33) | 28 (24, 34) | 0.3 |
| Alcohol Abuse | 310 (14%) | 222 (15%) | 36 (11%) | 52 (12%) | 0.15 |
| Blood Loss, Anemia | 519 (23%) | 386 (25%) | 66 (21%) | 67 (15%) | <0.001 |
| Cardiac Arrhythmias | 1,795 (78%) | 1,230 (80%) | 238 (74%) | 327 (74%) | 0.003 |
| Chronic Pulmonary Disease | 1,094 (48%) | 790 (52%) | 133 (42%) | 171 (39%) | <0.001 |
| Coagulopathy | 944 (41%) | 672 (44%) | 121 (38%) | 151 (34%) | <0.001 |
| Congestive Heart Failure | 1,029 (45%) | 733 (48%) | 135 (42%) | 161 (37%) | <0.001 |
| Deficiency, Anemia | 725 (32%) | 551 (36%) | 80 (25%) | 94 (21%) | <0.001 |
| Depression | 1,001 (44%) | 717 (47%) | 139 (43%) | 145 (33%) | <0.001 |
| Diabetes | 1,048 (46%) | 755 (49%) | 126 (39%) | 167 (38%) | <0.001 |
| Drug Abuse | 416 (18%) | 299 (20%) | 49 (15%) | 68 (15%) | 0.050 |
| Fluid and Electrolyte Disorders | 1,768 (77%) | 1,218 (80%) | 217 (68%) | 333 (76%) | <0.001 |
| Hypertension | 1,712 (75%) | 1,207 (79%) | 226 (71%) | 279 (63%) | <0.001 |
| Hypothyroidism | 528 (23%) | 379 (25%) | 70 (22%) | 79 (18%) | 0.009 |
| Liver Disease | 708 (31%) | 506 (33%) | 88 (28%) | 114 (26%) | 0.005 |
| Lymphoma | 225 (9.8%) | 156 (10%) | 37 (12%) | 32 (7.3%) | 0.10 |
| Metastatic Cancer | 516 (23%) | 355 (23%) | 78 (24%) | 83 (19%) | 0.10 |
| Obesity | 1,137 (50%) | 783 (51%) | 163 (51%) | 191 (43%) | 0.012 |
| Neurological Disorders | 802 (35%) | 587 (38%) | 98 (31%) | 117 (27%) | <0.001 |
| Paralysis | 329 (14%) | 243 (16%) | 44 (14%) | 42 (9.5%) | 0.003 |
| Peptic Ulcer Disease, Excluding Bleeding | 290 (13%) | 205 (13%) | 45 (14%) | 40 (9.1%) | 0.039 |
| Peripheral Vascular Disorders | 917 (40%) | 653 (43%) | 129 (40%) | 135 (31%) | <0.001 |
| Psychoses | 294 (13%) | 221 (14%) | 36 (11%) | 37 (8.4%) | 0.002 |
| Pulmonary Circulation Disorders | 778 (34%) | 555 (36%) | 104 (32%) | 119 (27%) | 0.001 |
| Renal Failure | 1,017 (44%) | 757 (50%) | 121 (38%) | 139 (32%) | <0.001 |
| Autoimmune Diseases | 407 (18%) | 293 (19%) | 56 (18%) | 58 (13%) | 0.014 |
| Solid Tumor Without Metastasis | 520 (23%) | 360 (24%) | 73 (23%) | 87 (20%) | 0.2 |
| Valvular Disease | 698 (30%) | 505 (33%) | 85 (27%) | 108 (24%) | <0.001 |
| Weight Loss | 822 (36%) | 614 (40%) | 100 (31%) | 108 (24%) | <0.001 |
| Oxygen Saturation | 95.57 (93.75, 97.28) | 95.56 (93.80, 97.29) | 95.53 (93.96, 97.50) | 95.67 (93.50, 97.10) | 0.7 |
| Temperature | 98.30 (97.93, 98.81) | 98.33 (97.95, 98.93) | 98.18 (97.87, 98.59) | 98.30 (97.92, 98.69) | <0.001 |
| Respiratory Rate | 19.7 (17.8, 24.0) | 19.5 (17.8, 23.7) | 19.6 (17.3, 23.2) | 20.5 (18.0, 24.9) | 0.003 |
| Diastolic Blood Pressure | 67 (61, 74) | 67 (61, 74) | 67 (60, 74) | 66 (60, 74) | 0.4 |
| Systolic Blood Pressure | 122 (110, 137) | 123 (110, 138) | 121 (110, 136) | 120 (109, 135) | 0.3 |
| Heart Rate | 85 (73, 98) | 85 (74, 98) | 84 (73, 95) | 85 (73, 99) | 0.5 |
| Respiratory Support | 0.6 | ||||
| No Respiratory Support | 1,376 (71%) | 918 (72%) | 189 (69%) | 269 (70%) | |
| Respiratory Support | 563 (29%) | 362 (28%) | 84 (31%) | 117 (30%) | |
| Affluence Quartile | <0.001 | ||||
| 1 | 530 (25%) | 391 (27%) | 66 (22%) | 73 (18%) | |
| 2 | 496 (23%) | 327 (23%) | 72 (24%) | 97 (23%) | |
| 3 | 547 (25%) | 333 (23%) | 79 (27%) | 135 (32%) | |
| 4 | 590 (27%) | 398 (27%) | 81 (27%) | 111 (27%) | |
| Disadvantage Quartile | <0.001 | ||||
| 1 | 659 (30%) | 398 (27%) | 103 (35%) | 158 (38%) | |
| 2 | 547 (25%) | 354 (24%) | 79 (27%) | 114 (27%) | |
| 3 | 445 (21%) | 316 (22%) | 49 (16%) | 80 (19%) | |
| 4 | 512 (24%) | 381 (26%) | 67 (22%) | 64 (15%) | |
| Ethnic Immigration Quartile | 0.011 | ||||
| 1 | 1,004 (46%) | 643 (44%) | 137 (46%) | 224 (54%) | |
| 2 | 777 (36%) | 533 (37%) | 114 (38%) | 130 (31%) | |
| 3 | 336 (16%) | 240 (17%) | 38 (13%) | 58 (14%) | |
| 4 | 46 (2.1%) | 33 (2.3%) | 9 (3.0%) | 4 (1.0%) | |
| Education Quartile | <0.001 | ||||
| 1 | 750 (35%) | 478 (33%) | 113 (38%) | 159 (38%) | |
| 2 | 708 (33%) | 450 (31%) | 100 (34%) | 158 (38%) | |
| 3 | 518 (24%) | 378 (26%) | 59 (20%) | 81 (19%) | |
| 4 | 187 (8.6%) | 143 (9.9%) | 26 (8.7%) | 18 (4.3%) | |
| Vaccination Status | 0.002 | ||||
| Not Vaccinated | 1,914 (84%) | 1,255 (82%) | 262 (82%) | 397 (90%) | |
| Partially Vaccinated | 84 (3.7%) | 61 (4.0%) | 15 (4.7%) | 8 (1.8%) | |
| Fully Vaccinated | 291 (13%) | 212 (14%) | 43 (13%) | 36 (8.2%) |
1
Median (Q1, Q3); n (%)
2
Kruskal-Wallis rank sum test; Pearson’s Chi-squared test