Table 3.

Adjusted associations between identified risk factors and mortality after the ICU admission, among the 2,289 patients with COVID-19 and stratified by dominant variant at diagnosis.

	A. Without Interactions			B. With Interactions by Dominant Variant
	All Variants		Original		Alpha		Delta
Characteristic	HR	CI	HR	CI	HR	CI	HR	CI
Age	1.03	(1.03, 1.04)	1.04	(1.03, 1.05)	1.04	(1.03, 1.05)	1.02	(1.01, 1.03)
Fluid & Electrolyte DiD	2.77	(1.95, 3.94)	3.19	(2.04, 4.99)	3.19	(2.04, 4.99)	1.60	(0.82, 3.13)
Vaccination Status
Not Vaccinated	-	-	-	-	-	-	-	-
Partially Vaccinated	0.44	(0.26, 0.75)	0.35	(0.18, 0.65)	1.66	(0.48, 5.76)	0.35	(0.18, 0.65)
Fully Vaccinated	0.32	(0.22, 0.46)	0.29	(0.19, 0.45)	0.75	(0.31, 1.78)	0.29	(0.19, 0.45)
Metastatic Cancer	1.42	(1.17, 1.73)	1.43	(1.14, 1.80)	1.43	(1.14, 1.80)	1.43	(1.14, 1.80)
Neurological DiD	1.49	(1.24, 1.80)	1.43	(1.15, 1.78)	1.43	(1.15, 1.78)	1.43	(1.15, 1.78)
Renal Failure	1.32	(1.09, 1.61)	1.12	(0.89, 1.41)	1.12	(0.89, 1.41)	2.59	(1.58, 4.25)
Oxygen Saturation	0.93	(0.89, 0.96)	0.94	(0.89, 0.98)	0.94	(0.89, 0.98)	0.94	(0.89, 0.98)
Respiratory Support
No	-	-	-	-	-	-	-	-
Yes	1.39	(1.12, 1.72)	1.34	(1.04, 1.73)	1.34	(1.04, 1.73)	1.34	(1.04, 1.73)
Unknown	1.06	(0.79, 1.42)	1.16	(0.83, 1.63)	1.16	(0.83, 1.63)	1.16	(0.83, 1.63)
Race
White	-	-	-	-	-	-	-	-
Black	0.98	(0.77, 1.25)	0.94	(0.71, 1.24)	0.94	(0.71, 1.24)	0.94	(0.71, 1.24)
Other/Unknown	1.45	(1.11, 1.90)	1.40	(1.03, 1.90)	4.35	(1.94, 9.76)	1.40	(1.03, 1.90)
Gray Level Nonuniformity	1.02	(0.88, 1.18)	1.01	(0.84, 1.20)	1.01	(0.84, 1.20)	1.01	(0.84, 1.20)
Zone Entropy	1.03	(0.92, 1.16)	1.10	(0.94, 1.28)	1.10	(0.94, 1.28)	1.10	(0.94, 1.28)
Gray Level Variance	1.18	(1.07, 1.31)	1.20	(1.06, 1.35)	1.20	(1.06, 1.35)	1.20	(1.06, 1.35)
Large Area High Gray	1.11	(1.01, 1.22)	1.12	(1.01, 1.25)	1.12	(1.01, 1.25)	1.12	(1.01, 1.25)
Level Emphasis

Note: HR, Hazard Ratio; CI, 95% Confidence Interval; DiD, Disorders.