Figure 3. . Percentage of excluded patients versus Shapely values by each eligibility criterion for APOLLO, POLLUX and ASPIRE trials using both Optum's electronic health records and Flatiron Health real-world databases.

Bootstrapped algorithm results are showed using confidence intervals. The black points represent the mean of bootstrapped Shapley values. The blue rhombus indicates results obtained by the same algorithm without bootstrapping. Eligibility criteria located in the blue zone led to less than 5% of real-world patient count exclusion, while the orange zone indicates eligibility criteria eligible for relaxation or removal (with both Shapley value and percentage of patients excluded higher than -0.01 and 5%, respectively).

ECOG: Eastern Cooperative Oncology Group; LOT: Line of therapy; PI: Proteasome inhibitor; WM: Waldenström’s macroglobulinemia.