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. Author manuscript; available in PMC: 2024 Jul 5.
Published in final edited form as: J Invest Dermatol. 2021 Jul;141(7):1630–1632. doi: 10.1016/j.jid.2021.01.003

Figure 1. Western diet-induced exacerbation of IL-23 mediated skin and joint disease can be mitigated with antibiotics or diet manipulation.

Figure 1.

Mice treated with (a) IL-23 minicircle DNA and placed on a (b) WD developed (c) worse psoriatic-like skin and joint disease accompanied by changes to the gut microbiota. In contrast, those fed a (d) CD exhibited (e) less severe skin and joint disease. Treatment of WD-fed mice with either (f) antibiotics or a switch to a CD alleviated disease. CD, conventional diet; WD, western diet.