TABLE 1.

Clinicopathologic Characteristics and Univariate Analyses of OS in Esophageal Cancer Patients Given Neoadjuvant Chemoradiotherapy (N= 7195)

Variables	n (%)	OS
		5-y OS (SE) (%)	Median Survival (mo)	Log-rank P
Age (y)				<0.001
≤60	2888 (40.1)	40.3 (1.21)	41.3
>60	4307 (59.9)	35.6 (1.00)	34.2
Sex				<0.001
Male	6054 (84.1)	36.1 (0.83)	35.5
Female	1141 (15.9)	45.3 (2.03)	51.5
Histology type				<0.001
EAC	5449 (75.7)	37.0 (0.89)	36.6
ESCC	1170 (16.3)	43.6 (1.86)	45.5
Adenosquamous carcinoma	58 (0.8)	39.8 (7.32)	31.3
Other types	518 (72.0)	28.6 (2.77)	27.1
Resected LNs				<0.001
<15	3775 (52.5)	35.5 (1.02)	33.2
≥15	3420 (47.5)	39.7 (1.16)	40.6
ypT stage (AJCC-8)				<0.001
ypT0	1752 (24.4)	51.8 (1.62)	62.6
ypTis/T1	1388 (19.3)	45.4 (1.82)	50.1
ypT2	1298 (18.0)	38.8 (1.80)	37.1
ypT3	2691 (37.4)	25.2 (1.11)	25.5
ypT4	66 (0.9)	8.18 (4.62)	14.9
ypN stage (AJCC-8)				<0.001
ypN0	4358 (60.6)	47.7 (1.01)	53.9
ypN1	1707 (23.7)	27.3 (1.46)	28.6
ypN2	798 (11.1)	15.7 (1.81)	21.8
ypN3	332 (4.6)	13.4 (2.86)	16.4
ypM stage (AJCC-8)				<0.001
ypM0	6960 (96.7)	38.6 (0.79)	38.2
ypM1	235 (3.3)	12.1 (2.23)	14.8
ypTNM (AJCC-8)				<0.001
I	3188 (44.3)	52.1 (1.19)	66.1
II	1081 (15.0)	37.9 (1.95)	36.9
IIIA	857 (11.9)	33.0 (2.29)	37.1
IIIB	1488 (20.7)	20.2 (1.41)	23.1
IVA	346 (4.8)	13.9 (2.73)	16.6
IVB	235 (3.3)	12.1 (2.23)	14.8
r-ypN stage				< 0.001
r-ypN0 (LNR = 0%)	4358 (60.6)	47.7 (1.01)	53.9
r-ypN1 (0%<LNR≤10%)	963 (13.4)	31.5 (2.03)	34.0
r-ypN2 (10%<LNR≤20%)	776 (10.8)	20.8 (2.07)	25.2
r-ypN3 (20%<LNR≤100%)	1098 (15.3)	15.5 (1.51)	19.8
r-ypTNM				<0.001
r-I	3188 (44.3)	52.1 (1.19)	66.1
r-II	1081 (15.0)	37.9 (1.95)	36.9
r-IIIA	509 (7.1)	36.9 (2.98)	40.3
r-IIIB	1159 (16.1)	23.2 (1.73)	26.5
r-IVA	1023 (14.2)	17.1 (1.63)	20.2
r-IVB	235 (3.3)	12.1 (2.23)	14.8

EAC indicates, esophageal adenocarcinoma; ESCC, esophageal squamous cell carcinoma; SE, standard error.