Table 2.

Multivariate Cox proportional hazard models: NSABP B-41

Variables	RFI (n = 519)		OS (n = 522)
	HR (95% CI)	p-value	HR (95% CI)	p-value
Treatment: L vs T	1.37 (0.80, 2.34)	0.26	1.46 (0.68, 3.11)	0.33
Treatment: TL vs T	0.70 (0.37, 1.32)	0.27	0.58 (0.22, 1.51)	0.27
Clinical tumor size (≥ 4.1 cm vs 2–4 cm)	2.42 (1.45, 4.02)	< 0.001	2.29 (1.12, 4.69)	0.02
Clinical nodal status (pos. vs neg.)	1.63 (0.99, 2.68)	0.06	1.26 (0.64, 2.49)	0.51
Hormone receptor status (pos. vs neg.)	0.59 (0.37, 0.93)	0.02	0.28 (0.14, 0.56)	< 0.001
Age (≥ 50 vs < 50 years)	0.71 (0.44, 1.14)	0.15	0.60 (0.30, 1.19)	0.14