Panel A shows Kaplan–Meier estimates of progression-free survival. Progression was determined through blinded, independent, central review and included imaging-based progression according to Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1, and clinical progression. Panel B shows a forest plot of progression-free survival in prespecified subgroups. FAP denotes familial adenomatous polyposis, NE not estimable, and TKI tyrosine kinase inhibitor.