Figure 2.

Ankle histology and histology scoring

(A) C57BL/6 (WT; n = 17) ankle joints had pronounced synovial hyperplasia and erosive changes (ankles collected on day 9 of KSIA; size bar is 500 μm on main image and 250 μm in the magnified area), while DUSP6 KO (n = 16) preserved a normal joint architecture with no significant synovial hyperplasia or erosions.

(B) Histology sections were scored as described, and DUSP6 KO mice had significantly lower scores for inflammation, synovial hyperplasia, and cartilage and bone erosions (t test, ∗∗∗∗p < 0.0001).