Table 1.
Baseline characteristics in patients who later converted to SSVD, AD, and mixed dementia as well as in stable SCI/MCI.
| Variable | SSVD (n = 15) | AD (n = 39) | Mixed dementia (n = 26) | Stable SCI/MCI (n = 249) | F-value or χ2 | P-value between groups | Partial η2 |
|---|---|---|---|---|---|---|---|
| Men/women (n,%) | 10/5 (67/33) | 14/25 (36/64) | 13/13 (50/50) | 104/145 (42/58) | 4.91 | 0.18 | 0.015 |
| Age (years) | 67.9 (6.8) | 65.5 (6.8) | 70.0 (6.4)a | 63.5 (7.2) | 8.41 | <0.001 | 0.072 |
| Education (years) | 11.5 (3.5) | 11.8 (3.4) | 11.2 (3.6) | 13.1 (3.5) | 4.04 | <0.01 | 0.037 |
| BMI (kg/m2) | 25.4 (3.2) | 23.6 (2.7) | 23.7 (3.5) | 25.1 (3.5) | 3.08 | <0.05 | 0.029 |
| MMSE score | 28.3 (2.1) | 27.8 (1.3)a | 27.7 (1.6)b | 28.7 (1.2) | 8.86 | <0.001 | 0.076 |
| Aβ1–42 (ng/L) | 560 (175) | 460 (141)a | 463 (176)b | 676 (217) | 7.67 | <0.001 | 0.068 |
| T-tau (ng/L) | 327 (103)c,d | 703 (475)a | 640 (313)a | 313 (149) | 34.89 | <0.001 | 0.249 |
| P-tau (ng/L) | 47.3 (8.3)e,f | 84.9 (42.1)a | 82.9 (40.9)a | 53.3 (26.5) | 17.06 | <0.001 | 0.149 |
| Smoking, yes/no (n,%) | 4/11 (27/73)e,f,g | 1/38 (3/97) | 1/25 (4/96) | 20/228 (8/92) | 9.35 | <0.05 | 0.029 |
| Hypertension, yes/no (n,%) | 7/8 (47/53) | 8/31 (21/79) | 10/16 (38/62) | 66/183 (27/73) | 5.39 | 0.15 | 0.016 |
| Diabetes, yes/no (n,%) | 2/13 (13/87) | 2/37 (5/95) | 0/26 (0/100) | 8/241 (3/97) | 5.37 | 0.15 | 0.016 |
| APOE4 allele, none/heterozygous/homozygous (n,%) | 8/6/1 (53/40/7) | 11/18/9 (29/47/24) a | 8/12/3 (35/52/13) | 140/77/15 (60/33/7) | 22.34 | 0.001 | 0.069 |
Values are given as means (SD). All patients had subjective or objective mild cognitive impairment (SCI/MCI) at baseline. APOE ε4 genotyping was not performed in 21 patients. Differences across groups were assessed using analysis of variance (ANOVA) followed by the Bonferroni post hoc test for continuous variables and using chi-square tests for nominal variables. F-values were calculated using ANOVA and χ2 values were obtained using chi-square tests. Partial eta square (η2) values were assessed using ANOVA or using chi-square tests.
p < 0.001 vs. stable SCI/MCI.
p < 0.01 vs. stable SCI/MCI.
p < 0.001 vs. AD.
p < 0.01 vs. mixed dementia.
p < 0.01 vs. AD.
p < 0.05 vs. mixed dementia.
p < 0.05 vs. stable SCI/MCI.