Table 4.
Baseline characteristics in the study population according to tertile of serum HDL concentrations.
| Variable | Tertile 1 (≤ 33rd percentile) (n = 119) | Tertile 2–3 (> 33rd percentile) (n = 207) | F-value or χ2 | P-value between groups | Partial η2 |
|---|---|---|---|---|---|
| Men/women (n,%) | 79/40 (66/34) | 60/147 (29/71) | 43.22 | <0.001 | 0.133 |
| Age (years) | 63.7 (7.1) | 64.8 (7.5) | 1.63 | 0.20 | 0.005 |
| Education (years) | 12.4 (3.6) | 12.9 (3.5) | 1.32 | 0.25 | 0.004 |
| BMI (kg/m2) | 26.6 (3.6) | 23.8 (2.9) | 54.01 | <0.001 | 0.149 |
| MMSE score | 28.5 (1.5) | 28.5 (1.3) | 0.01 | 0.92 | 0.000 |
| Aβ1–42 (ng/L) | 620 (200) | 630 (234) | 0.59 | 0.44 | 0.002 |
| T-tau (ng/L) | 323 (184) | 411 (297) | 7.67 | <0.01 | 0.024 |
| P-tau (ng/L) | 51.3 (22.0) | 63.4 (35.8) | 8.61 | <0.01 | 0.029 |
| Smoking, yes/no (n,%) | 13/105 (11/89) | 12/195 (6/94) | 2.88 | 0.09 | 0.009 |
| Hypertension, yes/no (n,%) | 38/81 (32/68) | 53/154 (26/74) | 1.50 | 0.22 | 0.005 |
| Diabetes, yes/no (n,%) | 7/112 (6/94) | 5/202 (2/98) | 2.56 | 0.11 | 0.008 |
| APOE4 allele, none/heterozygous/homozygous (n,%) | 59/45/7 (53/41/6) | 107/68/20 (55/35/10) | 1.90 | 0.39 | 0.000 |
Values are given as means (SD). All patients had subjective or objective mild cognitive impairment (SCI/MCI) at baseline. APOE ε4 genotyping was not performed in 20 patients. Serum HDL was determined in 326 patients (99 % of the total study population). Differences across groups were assessed using analysis of variance (ANOVA) followed by the Bonferroni post hoc test for continuous variables and using chi-square tests for nominal variables. F-values were calculated using ANOVA and χ2 values were obtained using chi-square tests. Partial eta square (η2) values were assessed using ANOVA or using chi-square tests.