Table 5.

The risk of conversion to SSVD according to tertile of serum lipid concentrations.

	Tertile 1 (≤ 33rd percentile)		Tertile 2–3 (> 33rd percentile)
	n (%) or HR (95 % CI)	P-value	n (%) or HR
HDL
SSVD, n (%)	12 (10.9 %)		3 (1.4 %)
Model A	7.29 (1.90 – 28.03)	<0.01	1.0 Referent
Model B	7.58 (1.78 – 32.28)	<0.01	1.0 Referent

	Tertile 3 (≥ 67th percentile)		Tertile 1–2 (<67th percentile)
	n (%) or HR (95 % CI)	P-value	n (%) or HR
Total cholesterol
SSVD, n (%)	3 (2.7 %)		12 (5.5 %)
Model A	0.58 (0.16 – 2.06)	0.40	1.0 Referent
Model B	0.56 (0.15 – 2.13)	0.40	1.0 Referent
LDL
SSVD, n (%)	5 (4.5 %)		10 (4.6 %)
Model A	1.05 (0.36 – 3.06)	0.94	1.0 Referent
Model B	1.17 (0.38 – 3.62)	0.79	1.0 Referent
Triglycerides
SSVD, n (%)	8 (7.3 %)		7 (3.2 %)
Model A	2.90 (1.04 – 8.08)	0.04	1.0 Referent
Model B	2.41 (0.78 – 7.46)	0.13	1.0 Referent
LDL/HDL ratio
SSVD, n (%)	8 (7.3 %)		7 (3.2 %)
Model A	1.90 (0.67 – 5.43)	0.23	1.0 Referent
Model B	1.99 (0.66 – 5.99)	0.22	1.0 Referent
Triglycerides/HDL ratio
SSVD, n (%)	10 (9.1 %)		5 (2.3 %)
Model A	3.78 (1.25 – 11.40)	0.02	1.0 Referent
Model B	3.47 (1.01 – 11.97)	0.049	1.0 Referent

Hazard ratios (HRs), 95 % confidence intervals (CIs), and p-values were calculated using Cox proportional hazards regression analyses. In terms of HDL, the lowest tertile was compared with the two higher tertiles. For other lipid variables, the highest tertile was compared with the two lower tertiles. Significant associations are marked with bold text. All patients had subjective or objective mild cognitive impairment at baseline. Moreover, all patients (n = 329) had values for TC and TG, whereas 326 (99 %) of the patients had values for HDL and LDL.

Model A: adjustment for age and gender.

Model B: adjustment for age, gender, education (years), BMI, current smoking (yes/no), hypertension (yes/no), diabetes mellitus (yes/no), and APOE ε4 allele.