Figure 3.

Metabolomic changes in plasma samples of patients with viral sepsis compared to viral non sepsis and combined pathway analysis with proteomic changes

Orthogonal partial least squares-discriminant analysis (OPLS-DA) of metabolites between viral sepsis and viral non-sepsis groups (A). Volcano plot displaying differences in metabolite levels between viral sepsis group and viral non-sepsis groups (B). Heatmaps showing top 25 differentially expressed metabolites between viral sepsis and viral non sepsis groups (C). Significantly enriched pathways and the corresponding differentially expressed metabolites (DEMs) between viral sepsis and viral non sepsis group (D). The interaction between DEMs and DEPs (E). The significantly enriched pathways using combined DEPs and DEMs (F).