REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Human plasma	This paper	N/A
Chemicals, peptides, and recombinant proteins
Acetonitrile	Fisher Chemical	Cat#75-05-8
Formic Acid	Sigma-Aldrich	Cat#64-18-6
Ammonium Bicarbonate	Sigma-Aldrich	Cat#1066-33-7
Dithiothreitol	Sigma-Aldrich	Cat#3483-12-3
Iodoacetamide	Sigma-Aldrich	Cat#144-48-9
Trypsin	Promega	Cat#9002-07-7
Acetone	Sigma-Aldrich	Cat#67-64-1
Ultra-pure water	This paper	N/A
Formic Acid	Fisher Chemical	Cat#64-18-6
Methanol	Fisher Chemical	Cat#67-56-1
Deposited data
Mass spectrometry proteomics data	This paper	https://proteomecentral.proteomexchange.org; ID：PXD050303
Untargeted metabolomic data	This paper	https://www.ebi.ac.uk/metabolights/MTBLS9664
Software and algorithms
GraphPad Prism 9.0	GraphPad Software, Inc.	https://www.graphpad.com
R	https://cran.r-project.org	V4.3.1
Biorender	Biorender	https://www.biorender.com/
Proteome Discoverer	Thermo Fisher Scientific (USA)	RRID:SCR_014477
UniProt	https://www.uniprot.org/	RRID:SCR_002380
MetaboAnalyst	https://www.metaboanalyst.ca/	RRID:SCR_015539
BiocManager package	https://bioconductor.org/	N/A
STRING	http://string.embl.de/	RRID:SCR_005223
MS-DIAL	http://prime.psc.riken.jp/compms/msdial/main.html	RRID:SCR_023076
IBM SPSS Statistics	https://www.ibm.com/products/spss-statistics	RRID:SCR_016479
HMDB	http://www.hmdb.ca	RRID:SCR_007712
Other
Vortex Mixer	Changzhou Enpei Instrument Manufacturing Co., Ltd	NP-30S
Mini Centrifuge	SCILOGEX	D1008E
High-Speed Refrigerated Centrifuge	SIGMA	1-15K
Analytical Balance	Mettler Toledo Instruments (Shanghai) Co., Ltd	AL104
Vacuum Centrifugal Concentrator	Thermo Fisher Scientific (USA)	SPD121P-230
Electrospray Ionization Hybrid Ion Trap-Orbitrap Mass Spectrometer	Thermo Fisher Scientific (USA)	Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer
High-Performance Liquid Chromatograph	Thermo Fisher Scientific (USA)	Vanquish
High-Performance Liquid Chromatograph	Thermo Fisher Scientific (USA)	Ultimate 3000
Mass Spectrometer	AB SCIEX™	TripleTOF5600+
Vacuum Centrifugal Concentrator	Eppendorf (Germany)	Concentrator plus
Analytical Balance	Sartorius (Switzerland)	Sartorius BP211d
Low-Temperature High-Speed Centrifuge	Beckman Coulter (USA)	Microfuge 22R Centrifuge
Mini Centrifuge	Scilogex (USA)	D1008
Vortex Mixer	Scilogex (USA)	MX-S